Seallagen MCT – Solution (Technical grade)

$175.50$1,755.00

Echinoderm Mutable Collagenous Tissue Solution

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Description

Echinoderms possess a unique connective tissue (Mutable Collagenous Tissue, MCT). Echinoderm MCT is composed by collagen fibrils interconnected by glycosaminoglycans, the major components of neodermis, creating the optimal environment for collagen biosynthesis, showing improved biocompatibility, biodegradability and safety. Echinoderm MCT unique physical, chemical and biological properties allow fabrication of stable hydrogels thorough fibrogenesis. It also constitutes a suitable polymeric matrix for electrospinning, 3D-bioprinting and biocompatible nanocoatings and cell culture R&D projects.

Applications

  • Cosmetic and nutritional supplements
  • Electrospinning and 3D-Bioprinting
  • Cell culture and tissue engineering
  • Biomaterials and nanotechnology

Testing

To ensure lot-to-lot consistency, this produce is tested by SDS-PAGE, HYP content, amino acid profile and FTIR to conform to characteristics of a standard reference collagen type-I (Human, Bovine and Rat Tail). Purity and retention of native helical structure was controlled by SDS-PAGE gel electrophoresis.

Results Diagrams

Comparative Analysis

Echinoderm Type-I Collagen constitutes an ideal standard for collagen purity (>98% collagen content), functionality, and one of the most native-like collagen available as of today.

①ME-Bio MCT shows oriented type-I collagen fibrils, depicting in improved stability and mechanical properties ②ME-Bio MCT shows excellent biocompatibility and safety, due to key biological properties and similarity to human type-I collagen ③Purity analysis by native gel electrophoresis, showing type-I collagen high molecular weight (>250 kDa) and nativity as indicated by the presence of triple helix microfibrils β,α1 and α2

Key Features

Optical and scanning electron microscopy images showing echinoderm type-I collagen fibrils and arrangement of mutable collagenous tissue. The image above shows the stability of collagen to thermal and chemical degradation when compared to other collagen sources.

Biological Information

Natural Extra Cellular Matrix
Mutable collagenous tissue is a unique natural extracellular matrix composed by collagen and glycosaminoglycan, the major components of neodermis, creating the optimal environment for new collagen biosynthesis and promoting integrin binding.

Safe Source of Collagen
Mutable collagenous tissue is extracted from echinoderms and its microstructure bears some resemblance to the connective tissues of humans.

Cell Culture Friendly
Echinoderm MCT unique composition provides the most suitable environment for cell attachment, proliferation and differentiation, becoming the most reliable matrix for 2D and 3D culture experiments.

The illustration above shows the molecular arrangement of mutable collagenous tissue, composed by an interconnected and organized network of type-I collagen and glycosaminoglycans, the two major components of connective tissues.

Product Details

Protein Molecular Weight: 150 – 300 kDa.
Conformation: Triple-helix of beta and two alpha[2(l)and 1(1)] chains.
Tissue Specificity: Echinoderm Mutable Collagenous Tissue (MCT), echinoerm mutable collagenous tissue (MCT), composed by collagen fibrils interconnected by glycosaminoglycans, creating a suitable environment for collagen biosynthesis and cell growth.